Our ability to mark individual proteins as either accelerating or decelerating in their discovery rates can be used to identify hot and cold discovery regions within the mammalian PPIN.
The subsurface oil "is not a new discovery," Navy Region Hawaii said in an email to The Huffington Post.
In addition, it facilitates the discovery of regions such as the C-terminal area that displays weak secondary structure propensities but no disorder propensity, and disordered flanks that have a propensity for alpha-helical conformation.
We propose a view-dependent spatiotemporal saliency-driven approach that facilitates the discovery of regions showing high levels of spatiotemporal variability and reduces the rendering intensity of interactive visualization.
These tools would be an excellent choice especially for applications such as de novo motif discovery in regions with multiple motifs, where it is important to accurately minimize sequence search space.
The discovery of regions of allele-specific chromatin structure is consequently important for the interpretation of variants and their phenotypic effects in genome-wide association studies (GWAS) [ 16, 17].
Although GWAS studies are important for discovery of regions of the genome important in disease, they have not always proven to be useful in validation of functional markers due to the all-inclusive approach applied for cases and controls.
The proteogenomic queries available through VESPA enable the discovery of regions of mis-annotations in a rapid manner, which can reduce the number of candidate reading frames for evaluation.
The identification of these regions should use the information about the probability of alteration (to avoid giving the same weight to probes with strong and weak evidence of alteration), and should allow the discovery of regions over subsets of samples as it is known that many complex diseases, such as cancer or autism, are composed of subtypes of syndromes (Sebat, 2007).
As for genome-scale techniques, association mapping approaches that correlate genomic variation with phenotype variation allow for the discovery of regions under selection and candidate genes underlying the emergence and diversification of these traits, paving the way for further studies of their function [ 49].
