Sentence examples for discovery rational from inspiring English sources

Such information will likely prove to be crucial in cancer prognosis, diagnosis, prevention, and therapy, with the ultimate goals being therapeutic target discovery, rational drug design, and identification of early-detection surrogate biomarkers (Pandey and Mann, 2000; Rudert, 2000).

The study may facilitate the discovery and rational design of novel leads with potent inhibitory activity targeting Raf-1 kinase.

In particular, the examination of functional binding sites is of importance in biological chemistry and drug discovery by rational design [2].

Several tools have been developed and in some cases already tested in human trials, which will greatly support the discovery and rational design of novel vaccines against difficult targets such as HIV, malaria, TB, dengue, and S. aureus, where conventional technologies have failed.

It is often denied that any scientific discovery could give rational grounds for questioning this fact.

This discovery introduces a rational approach to design and synthesize new alloys for hydrogen storage using the concept of binding energy engineering.

The novel synthesis technique and revealed electronic coupling mechanism described herein opens the door for the rational discovery of other bimetallic nanocatalysts with positive synergy.

Accurate knowledge of the surface reaction rate constant, is essential for both optimal design of components using existing materials and rational discovery of new materials with enhanced catalytic activity.

A recent trend in drug design and discovery is the rational design or serendipitous discovery of novel drug entities with the ability to address multiple drug targets that form part of the complex pathophysiology of a particular disease state.

It's true that Merck was early among pharmaceutical companies to shift the focus of its research from chemistry-based screening isolating new compounds and testing them in vivo to assess the effects to biology-based "rational discovery". But Eli Lilly had great research too.

Molecular modeling studies led to the rational discovery of N1-arylsulfonyl-1,3-dihydro-2H-benzimidazol-2-one as a novel template for the design of new non-nucleoside reverse transcriptase inhibitors (NNRTIs) that are active against wild-type and mutant strains of HIV-1.