Sentence examples for discovery of transcripts from inspiring English sources

This allows discovery of transcripts not present in a reference genome or transcriptome.

Thus, de novo assembly is most fruitfully applied in the context of large-scale discovery of transcripts expressed in species with poorly characterized or absent reference genomes.

Additionally, our approach to EST collection has limited the discovery of transcripts known to be rare, such as for the SUPERMAN gene [ 56].

The discovery of transcripts that might be involved in the biosynthesis of alkaloids, flavones/flavonoids, phenylpropanoids and terpenoids will facilitate the elucidation of bioactive compound biosynthetic mechanisms at the molecular level in the Huperziaceae (see Additional file 2).

Within each silk gland type, the spidroins are highly expressed [ 34], which impedes the discovery of transcripts expressed in lower abundance, yet may nevertheless play important roles in silk production.

Recent discoveries of transcripts derived from yeast and vertebrate telomeres, as well as rasiRNAs derived from Drosophila melanogaster telomeric retrotransposons, suggests the involvement of non-coding RNAs in telomere structure and telomere regulation across species (Savitsky et al, 2006; Azzalin et al, 2007; Schoeftner and Blasco, 2008).

Assays that previously required multiple platforms, or which were simply not available, now can be performed from a single sequencing data set; e.g. transcript quantitation, isoform identification, alternative splicing and transcription start sites, allele-specific transcription, and discovery of novel transcripts.

Using the Cuffdiff algorithm to calculate differential expression at the transcript level allowed discovery of which transcripts are common, differentially expressed or present/absent between normal and AD brain tissue.

High-throughput generation of sequences from DNA or RNA has enabled the discovery of rare transcripts, such as alternatively spliced or fusion transcripts, as well as transcripts with low abundance [ 31, 32].

The high number of sequenced reads resulted in significant coverage of the transcriptome in leaves, allowing gene discovery, quantification of transcripts in four pools and the identification of putative SNPs and SSRs.

The alignment of more than 65 million high-quality short reads to the Ae. aegypti reference genome permitted the refinement of the current annotation of transcript boundaries, as well as the discovery of novel transcripts, exons and splicing variants.