Sentence examples for discovery of substrate from inspiring English sources

Here, we present a surface patch ranking (SPR) method for in silico discovery of substrate specificity-determining residue clusters by exploring both sequence conservation and correlated mutations.

The discovery of substrate pool fluctuations in a cell (filling/depletion) was made during studies of isotopic ratios of different photosynthesizing organisms.

Here we highlight screening methods that can be used for the discovery of substrate phosphorylation site inhibitors, with a focus on benefits and potential pitfalls of each method.

These examples highlight that although activity based assays can be biased toward identifying ATP-noncompetitive inhibitors, the discovery of substrate phosphorylation site inhibitors from such assays remains elusive.

Despite the promise of competitive binding assays for the discovery of substrate phosphorylation site inhibitors, these screens have not yet been used for the identification of substrate phosphorylation site inhibitors.

In this study, we present a novel algorithm for the discovery of substrate cycles in large scale metabolic networks by identifying cyclical EFMs in hierarchical modules designed to preserve cyclical interactions using our ShReD metric.

We developed a strategy to aid the discovery of substrates for any given kinase and demonstrated its utility with the yeast Ste20p kinase.

The discovery of substrate-selective inhibition provides a mechanism by which 2-AG oxygenation may be pharmacologically distinguished from AA oxygenation in vivo.

The recent discovery of substrate-selective inhibition may provide an approach for determining the role of COX-2-dependent oxygenation in modulation of endocannabinoid tone.

We also discuss how this discovery of substrate-dependent ATPase activity of PPIP5K provided an opportunity to gain new insight into the reaction mechanism of this particular kinase.

We recently reported the discovery of substrate-competitive c-Src inhibitors using a substrate activity screening (SAS -based approach (vide infra).