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We describe computational identification of membrane proteins and prediction of their topology from sequence, discovery of sequence and spatial motifs, and implications of these discoveries.
Here we report a method for engineering novel βMPs based on the discovery of sequence motifs that predominantly interact with the cell membrane and appear in more than 75% of transmembrane strands.
The International HapMap Project was established in 2002 with the primary aim of determining the common patterns of DNA sequence variation in the human genome in order to facilitate the discovery of sequence variants that affect common diseases [1].
Discovery of sequence motifs was performed with the use of the TEIRESIAS algorithm [ 25].
The same enhanced discovery of sequence conservation was also observed when evolutionarily distant nematode or vertebrate species were compared.
This hypothesis has been supported by the discovery of sequence changes of these DNA-binding domains for human and yeast DNA polymerases [ 158, 159].
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The latter have been considered preliminary to the discovery of sequences or laws.
The discovery of sequence-specific gene silencing by endogenous double-stranded RNAs (dsRNA) has propelled synthetic short-interfering RNAs (siRNAs) to the forefront of targeted pharmaceutical engineering.
Identification and mapping of Prx genes in barley provides new markers for genetic mapping and for the discovery of sequences that may characterize resistance QTLs.
SINCE the discovery of sequence-specific binding of the λ-phage repressor to operator sites (Gilbert and Müller-Hill Müller-Hillne 1967), the Ptashnele of sequence-specific binding has been a key to understanding gene regulation, DNA replication, genome defense, and other basic genetic processes.
This information can also be used for other objectives such as the discovery of sequences important in X-chromosome inactivation, and the subsequent prediction of expression status of individual genes [ 24].
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