The discovery of markers that allow the prospective isolation of stem cells and their progeny from their in vivo niche allows the functional properties of purified populations to be defined.
In 1987, he described advances in identifying genetic markers on human chromosomes: "Before the discovery of markers, chromosomes were like unnumbered avenues; the markers are like cross streets that enable a gene to be placed, say, between 15th Street and 16th Street along the avenue of the chromosome".
LevelsDB was created to facilitate the discovery of markers for cancer detection, and emphasis was given to publications with data for normal controls as well as cancers.
Furthermore, given the reported trend of biased patterns of gene loss/retention post polyploidization [ 66], combining standard di-allelic and ploidy-reduction SNPs will likely target genes from different functional categories, useful for future discovery of marker-trait relationships.
Discovery of markers may add additional information, increasing the validity of clinical estimates and permitting early, aggressive, and effective sepsis therapy.
A map would allow the discovery of markers linked to gene(s) or chromosome regions that are responsible or involved in the expressions of introgressed characteristic.
The sequenced regions for blight resistance as well as any future desirable QTL have an additional utility beyond candidate gene discovery; they will enable discovery of markers for fine mapping and marker assisted selection.
The discovery of markers for the physiological (e.g., alveolocapillary hyperpermeability) or histological (hyaline membrane) hallmarks of ARDS is of great import for the identification of a specific phenotype within ARDS.
The study is a first step towards a deeper understanding of enzymes and regulators involved in pathways of androstenone metabolism and may ultimately lead to the discovery of markers to reduce boar taint.
A complementary approach to QTL mapping is association mapping, which relies on historical recombination events of many different lineages for the discovery of markers linked to the trait of interest.
