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Doing so prevents the discovery of interaction effects among genes which are not, by themselves, discriminative.
We selected two studies that included both discovery of interaction and its replication in additional samples [ 22, 23].
Complex interaction models that distinguish between node and link types are useful when the focus of study is on a small molecular subsystem but a hindrance when the aim is the discovery of interaction patterns across large sets of interactions.
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Particularly for these markers, discovery of interactions can provide clues as to their potential mechanisms of action that may facilitate gene-function studies.
The discovery of interactions between EIAV Rev and RBR-2 is consistent with previous reports that the complete 555 nt ERRE has more functional activity in vivo than several shorter ERRE-derived constructs that encompass the ESE region but lack RBR-2 [29].
It can also be used for descriptive discovery of interactions, among other descriptive analyses.
Caution is required; neglect during first-round selection can prevent discovery of interactions or cause underestimations of metabolic potential.
Over time, it is becoming evident that discovery of interactions is a standing challenge for the genetics of complex diseases.
The method is particularly suited for the discovery of interactions between peptide binding domains and their targets.
However, the results from 3C assays are limited to a pre-selected region, excluding the discovery of interactions with regions beyond the tested genomic window.
As expected, the discovery of interactions as well as disease-association for a given gene provides additional biological knowledge, allowing inferences as to its genomic functionality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com