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The discovery of HPV as a causative agent in HNSCC represents an important shift in the epidemiology of this cancer.
Systematic discovery of HPV vaccine targets relies heavily on the availability of accurate, up-to-date and well-organized antigen data.
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These data could have profound implications on the focus of drug discovery for HPV therapeutics and suggests a re-analysis of current target strategies.
According to our protocol of follow-up after the discovery of an HR-HPV infection in normal smears, two HR-HPV-positive HSIL were diagnosed at the cytological and histological examinations at a third control at 31 months in a 45-year-old woman and at 38 months in a 25-year-old women.
The protocol that we applied after the discovery of an HR-HPV infection in women with normal smears clearly induces a bias increasing the number of HSIL early detected and largely explains the absence of detection of such lesions after 4 years of follow-up.
One of the research interests of our group at the Dana-Farber Cancer Instheute is the discovery of T cell-based HPV vaccine targets.
Zur Hausen was given half the award in recognition of his discovery of the human papilloma virus (HPV) and its link to cervical cancer.
Our discovery that HPV E7 influences the expression of SIRT1 provides the first link between an oncogenic virus and the aging-related SIRT1 protein, and enables access to diverse SIRT1-dependent cellular regulatory systems.
We propose that the observations in both the plant and animal kingdoms described above, taken together with the discovery of H. pylori, the finding that EBV can transform lymphocytes into cancer [ 213], and the identification of HPV 16 DNA [ 214] and HPV 18 [ 215] in cervical cancers (HPV infection is a precondition for about 75% of human cervical cancers) further support our hypothesis.
Public awareness of HPV as a risk factor lags behind these scientific discoveries.
However, the discovery of the human papillomavirus (HPV) as a necessary factor for developing cervical cancer has led to the introduction of HPV DNA testing and HPV vaccination, which may improve the health and economic outcomes of cervical cancer prevention.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com