Sentence examples for discovery of efficacious from inspiring English sources

Identifying methods to improve assay sensitivity in randomized clinical trials (RCTs) may facilitate the discovery of efficacious pain treatments.

Thereby, a concerted inquiry is needed to decipher the mechanisms of NDDs, and accelerate the discovery of efficacious therapies.

This method may facilitate rapid discovery of efficacious direct drug conjugates by allowing informed selection of linkers and cargo based on endocytic trafficking.

Hence, the discovery of efficacious MMP inhibitors without strong zinc-binding functional moieties is a very active field of research toward the generation of clinical treatments for those serious conditions.[ 16] Peptide bonds of the protein backbone represent the ubiquitous binding motif for small molecules to modulate a biological target.

Recently, the discovery of effective drugs to counteract the adverse impacts of formaldehyde on the central nervous system and promoting the survival of neuronal cells, has become of great interest to many neuropharmacologists. TongLuoJiuNao (TLJN), a traditional Chinese medicine (TCM), is clinically efficacious in the treatment of ischemic cerebral stroke and dementia (Chinese SFDA: 2004 L0162004

The solution to problems associated with contamination and resistance to antimicrobials could lie in the discovery of new, affordable, efficacious antimicrobial compounds.

Structure-guided design of inhibitors of thrombin (factor IIa, fIIa) and factor Xa (fXa) eventually led to the discovery of potent, selective, efficacious, orally active and safe compounds that proved successful in clinical studies.

These approaches will hopefully facilitate the discovery of safer, more efficacious anticancer drugs that exploit vulnerabilities that are unique to cancer cells by virtue of the mutations they have accrued during tumor progression.

Exploration of phenylimidazole substitution led to the discovery of potent, selective and efficacious inhibitors of TF FVIIa.

However, since the discovery of BACE1, medicinal chemistry toward the development of efficacious inhibitors has proved to be a challenging task [11], [12], [13], [14], [15].

Knowledge of significant signaling pathway networks will provide important clues and clear directions for an in-depth investigation of pituitary adenomas, for the discovery of tumor biomarkers, and for the development of efficacious therapeutic agents.