We demonstrate that the computation of all densely connected and co-expressed regions in interaction networks is an approach to module discovery of considerable value.
A discovery of considerable interest regarding fresh frozen bone allograft is described in a recent in vitro study by Board et al. (2008).
The discovery of considerable similarities in the SLI pattern of all three species leads to the question of the ancestral pattern of Pycnogonida.
Until recently, it was thought that only the paternal genome undergoes active demethylation in the early embryo; however, the discovery of considerable amounts of 5hmC and 5fC in both pronuclei suggests that it may also affect the maternal genome to some extent (Wang et al., 2014).
Hume goes on to observe that this "discovery" is of considerable importance "for deciding all controversies concerning ideas".
Since the discovery of rapamycin, considerable progress has been made in unraveling the details of the mammalian target of rapamycin (mTOR) signaling network, including the upstream mechanisms that modulate mTOR signaling functions, and the roles of mTOR in the regulation of mRNA translation and other cell growth-related responses.
Subsequently, this led to the discovery of a considerable number of other domain-swapped proteins, such as some ribonucleases [6], [7], [8], cysteine proteinase inhibitors [9], [10], [11], SH2 and SH3 domains [12], [13], L-histidinol dehydrogenase [14], glyoxalase I [15], nitric oxide synthase [16], suppressor of cyclin dependent kinase [17], [18], and prion proteins [19].
Although the discovery of LPMOs attracted considerable attention due to their beneficial use in biomass conversion to biofuels, to date, only 14 fungal AA9 LPMOs have been biochemically characterized [ 4– 14, 14, 31, 36].
Back in the rookie days of his coaching career, as a promising young manager taking his first foray into the dugouts of Serie A, the 1990-91 season was a voyage of considerable discovery for Claudio Ranieri.
Massively parallel next generation sequencing, which enables the discovery of such changes, uses considerable quantities of genomic DNA (> 5 ug), a serious limitation in ever smaller clinical samples.
In little over 20 years since the discovery of the telomerase enzyme, considerable progress has been made in unravelling the molecular mechanisms underlying the control of this unique mode of chromosome end replication.
