The rigorous silencing phenomenon enabled us to analyze methylation in a number of the transgenic lines in parallel, which led to the discovery of a consensus target region for de novo methylation, which comprised an asymmetric cytosine (CpHpH; H is A, C or T) sequence.
Since the discovery of the consensus sequences, mutations in the surrounding regions have also been known to influence the output of gene expression, with vertical scaling of the expression response curve over as much as 3 4 orders of magnitude.
An indication that the latter may be the case is the fact that several ChIP-Chip and ChIP/PET investigations have led to the discovery of new consensus binding sites e.g., both Smeenk et al. [ 11] and Wei et al. [ 12] present new TP53 motifs based on whole genome ChIP analyses.
But although the coincidence of \ \textbf{P}\) and \ \textbf{NP}\) would have intriguing consequences, it also seems likely that the discovery of a proof validating the consensus view that \ \textbf{P} \neq \textbf{NP}\) would be regarded as foundationally significant.
If the authors' discovery of ATGACGTGAT as a new consensus for fly Aft-2 were true, it would disrupt this palindrome.
Expansion of the NES consensus upon discovery of minus NESs leads to improved coverage of potential NESs, thus allowing identification of previously unrecognized NESs in known and new CRM1 cargos.
The absence of consensus sequences for cleavage sites and the discovery of possible multiple proteolytic steps render predictions of N-termini difficult.
Identification and comparing the cis-motif consensus pattern and discovery of expression modules within gene co-expression networks are crucial to understand the common regulatory networks.
Our study reports the discovery of about 883 K high quality consensus InDels using these two packages followed by stringent filtration criteria, and discusses the physical and functional characteristics of these InDels.
"Before this discovery, the consensus was that planets simply cannot influence the evolution of their parent star, and cannot survive being swallowed by a red giant star," Stephane Charpinet, of the University of Toulouse in France, told SPACE.com in an email.
