Sentence examples for discovery of compounds from inspiring English sources

Technology has helped with the early part of the process, the discovery of compounds, but not as much with the costliest and most time-consuming portion of drug development -- clinical trials.

The discovery of compounds targeting Wnt signaling pathway has great potential to become a therapeutic strategy for colon cancer treatment.

Optimization of 1a using docking studies led to the discovery of compounds 1b and 1d, potent JAK2 inhibitors.

Syntheses and SAR are described, which led to the discovery of compounds with high binding affinity (Ki = 1 nM) for the receptor.

It is likely that such an approach will complement the molecular diversity of organic chemistry in the quest for the discovery of compounds with superior biological activities.

Here we report the discovery of compounds 6 and 9 using a rationally designed kinase-directed library which potently inhibit Eph receptor tyrosine kinases, particularly EphB2 with cellular EC50s of 40 nM.

This led to the discovery of compound 38 which successfully progressed into clinical development.

Medicinal chemistry efforts led to the discovery of compound 4e with potent cellular activity and good oral bioavailability in dog.

After the discovery of compound 1, a series of novel tetrahydrophthalimidobenzoate derivatives were designed and synthesized, and some synthesized compounds exhibited good herbicidal activity in controlling broadleaf weeds.

Further optimization of pharmacokinetic properties of these compounds led to discovery of compound 74, which exhibited anxiolytic effect in the rat Vogel conflict model.

Furthermore, investigation of the phenoxypiperidine part of compound 14 resulted in the discovery of compound 19, which showed potent sEH inhibitory activity (sub-nM sEH IC50 values).