I outline four reasons why bioinformaticians are newly enabled to drive the questions in primary medical discovery: public availability of data, intersection of data across experiments, commoditization of methods, and streamlined validation.
The ability of BNCT to fulfill its clinical therapeutic potential thus clearly rests on the discovery and availability of effective and safe boron transport agents.
However, with the discovery of IL-17, and availability of newer reagents, a different role for IFN-γ has emerged in recent years.
In the context of a drug discovery effort, the availability of a robust crystallographic system is a means to understand the subtle differences between ATP competitive inhibitor interactions with the active site and their selectivity against other PI3Kinase enzymes.
The discovery of osteoinductive BMPs and their availability in recombinant human forms has given considerable impetus to the field.
Genome-wide transcriptomic profiling is particularly well-suited for the discovery of molecular markers3 given the availability of techniques such as microarrays4 and RNA sequencing (RNA-Seq 5,6, RNA-Seq 5owhichultallowsimultaneoust of tens of thousands of protein-coding and non-coding genes in a given sameasurement
The discovery of substandard antimalarials and the availability of drugs that are outside of national policy and guidelines warrant an effective drug quality surveillance system and more stringent antimalarial drug regulation in Afghanistan.
Nevertheless, despite recent discoveries and availability of novel β-glucosidases from uncultured microbes (for examples see ref. [ 19- 24]), their potential for the enzymatic conversion of lignocellulose into fermentable sugars has not been assessed as yet.
Effective drug discovery demands the availability of microgram to gram quantities of high-quality protein encoded by novel transcripts.
However, the recent advances in genome sequencing projects, particularly the discovery of vast numbers of SNPs and their availability in affordable arrays, have opened the door to a new era in gene discovery.
