The discovery of the activation of ROS-mediated apoptosis by the curcumin analog WZ35 may provide new strategy for curcumin-based anticancer drug design and development.
Our discovery of an activation platform formed by CL/Caspase-8/Bid-FL at mitochondrial contact sites opens various possibilities for research.
This role was later found to be fulfilled by intramitochondrial Ca2+, following the discovery of the activation by Ca2+ of mitochondrial enzymes, as discussed above, namely the matrix dehydrogenases PDH [31], NAD-ICDH [37], OGDH [9], and possibly the ATP synthase [59].
This presentation will provide an overview of the molecular-based discoveries in the area of hypothermic preservation with focused discussion on the recent discovery of the differential activation of the UPR (unfolded protein response) pathway and its impact on the response of cells and tissues to cold storage.
The discovery of ATGL and its activation by CGI-58 provided a mechanistic explanation for the pathogenesis of neutral lipid storage disease (NLSD) in humans.
The discovery of additional ligands and activation pathways, especially for other more numerically dominant Vδ2neg cells (namely Vδ1pos), is keenly awaited.
The discovery of intrinsic var gene activation biases and their associations with chromosomal locations and other genetic features could therefore have important implications for future studies.
The data from these assays were critical in the optimization of the molecular leads and in the discovery of a pharmacophore for TpoR activation.
Yeast surface display has proven to be a powerful tool for the directed evolution of immunological proteins when soluble ligands are available (Cho, B.K., Kieke, M.C., Boder, E.T., Wittrup, K.D., Kranz, D.M., 1998. A yeast surface display system for the discovery of ligands that trigger cell activation. J. Immunol. Methods 220, 179; Boder, E.T., Midelfort, K.S., Wittrup, K.D., 2000.
Nevertheless, the discovery of different modes of JNK activation may provide a partial explanation to this appparent paradox.
