They are often disadvantaged by poverty, abuse, medical and psychiatric illness, or late discovery of fetal abnormalities.
Although proteomic abnormalities are documented in patients with CIRS-ciguatera, it is relatively difficult to measure protein expression on a global scale and the future discovery of proteomic abnormalities may be slow.
The use of neuroimaging revealed in three cases the discovery of incidental benign abnormalities (Chiari I malformation, arachnoid cyst, non-specific white matter abnormalities).
According to practice parameters published by the American Academy of Neurology and the Child Neurology Society [19], our data confirm that EEG is not recommended in the routine evaluation of headache, as it is unlikely to define an etiology and may lead to the discovery of incidental benign abnormalities, with subsequent unnecessary investigations and hospital admission.
The discovery of recurrent molecular abnormalities, like JAK2V617F and MPLW515L/K mutations [1], has reinforced the Dameshek's vision that these disorders have a common pathogenetic mechanism and presumably belong to an unique disease process [2].
Differential prognosis of cytogenetically normal AML (CN-AML) has been allocated by the discovery of specific molecular abnormalities.
With the advent of next generation sequencing (NGS) technologies the discovery of novel molecular abnormalities has accelerated.
One of the main advantages of CMA over chromosome analysis is its ability to detect small CNVs, enabling discovery of mosaicism for abnormalities not previously detectable.
In primary MDS, the discovery of nonrandom chromosomal abnormalities confirmed the clonality, providing a way to identify the malignant clone and point out some oncogenes and tumor suppressor genes, possibly involved in the development and in the leukemic transformation.
Therefore, transcriptomic studies of carefully selected samples can unveil new diagnostic markers and transcriptional signatures highly specific of PC, and lead to the discovery of novel genomic abnormalities that may provide additional insights into the causes and mechanisms of prostate cancer.
