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In order to characterize A/H5N1 viral sequences, a bioinformatics approach accurately identified viral sequences from discovery of a sequence signature, which provided enough distinctive information for sequence identification.
Molecular analysis may then lead to the discovery of a sequence of DNA that codes for an unusual protein that is in part responsible for the development of the symptoms of the disease.
The identification of a large number of hot spots led to the discovery of a sequence motif bound by a zinc finger protein, PRDM9, at about the same time that mouse geneticists also discovered that PRDM9 promotes recombination (McVean and Myers 2010; Baudat et al. 2014).
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The discovery of a unique sequence is critical to authenticate results in such controversial areas as paleomicrobiology (5).
This theory is supported by the discovery of a conserved sequence at exon-intron boundaries, called the protosplice-site (MAG/R) [ 24], which is believed to be a specific target site for newly gained introns, or a preferential site for intron fixation.
Exceptions to the pattern, for instance, failure to find orthologous sequences in the same location, or discovery of an unrelated sequence in a homoeologous position, are powerful indicators of evolutionary mechanisms.
In the present study, the discovery of a complete mt genome sequence for H. contortus in a GSS database allowed the direct evaluation of the 454 sequencing output, and did not reveal any sequencing errors.
Yet, the preceding 20-year journey the discovery of a strange microbial repeat sequence; its recognition as an adaptive immune system; its biological characterization; and its repurposing for genome engineering remains little known.
Eight years ago the discovery of a host cell targeting sequence present in both soluble and transmembrane P.
Our discovery of a mosaic L segment sequence, which is descended from two major circulating lineages of SFTSV in China, represents the first evidence that homologous recombination plays a role in SFTSV evolution.
Then we step through elements of the workflow in greater detail, including a brief overview of the discovery of sequence variations from high-throughput sequence data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com