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"We believe damages could be in the billions of dollars, particularly if there is discovery of a defect in Toyota's electronic throttle control system as we suspect," Craig Hutson, a senior investment grade analyst at Gimme Credit, a bond research service, wrote in a note to clients on Thursday.
When the factors responsible for this regulation were studied, a hip3 mutant was isolated via discovery of a defect in the transcriptional repression of meiosis-specific genes.
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A major advance in our understanding of cholesterol transport was the discovery that a defect in ABCA1 blocks the efflux of cholesterol and phospholipids from cells to apoA1 to form circulating HDL [1], [2], [32] [34].
Until recently, all characterised TNR diseases were human-specific, but the recent discovery of a TNR mediated genetic defect in Arabidopsis thaliana[ 13] supports the idea that both the mechanisms and the underlying causes are cross-species phenomena.
The discovery of field defect markers could be of great use in mucosa that appears normal, both for early detection and risk assessment for colon cancer (such as MGMT promoter methylation in CRC) [25], [45].
Motivated by the recent discovery of a tri-nucleotide repeat associated genetic defect in Arabidopsis thaliana, this study takes a cross-species approach to investigating these repeat tracts, with the goal of using commonalities between species to identify potential disease-related properties.
The discovery of a spine morphological phenotype indicates a possible defect in synaptic plasticity in FXS.
Taking ion channelopathies as an example, the discovery of genetic defects involving the L-type Ca2+ channel (Cav1.2), ryanodine receptor (RyR2), and calsequestrin has provided incontrovertible evidence linking cardiac arrhythmias to abnormal intracellular Ca2+ cycling.
Recent years have seen an explosion in the rate of discovery of genetic defects linked to PD. Different racial and geographical populations may have different distributions of genetic variants.
She noted that the discovery of birth defects, which often occurs in the second trimester, was a common reason for later abortions.
Direct evidence for a defect in oxidative phosphorylation in HD patients is supported by the discovery of a threefold increase in lactate concentrations in the occipital cortex and in the basal ganglia (Jenkins et al 1993).
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