However, it is unclear what precise mechanism of action of afatinib this relates to and further mechanistic insights and biomarker discovery are required to decipher this.
In order to expedite progress and to make more efficient use of limited resources, new strategies for biomarker discovery are required that make greater use of archived samples from longitudinal studies (Zhu et al, 2011).
But the California Department of Public Health fined the hospital $250,000, the maximum allowed, for failing to report the breach within five days of discovery, as is required under state law.
In a distributed P2P system, a discovery algorithm is required to locate specific information, applications, or users within the system.
Fundamentally, to embark on, or refine philanthropic or social investment, a discovery phase is required.
In order to fully exploit the privileged nature of natural products in antibiotic drug discovery, what is required is the ability to rapidly identify scaffolds, tailor them using a collection of modifying enzymes, and rapidly purify the resulting compounds in sufficient quantity to generate libraries of molecules suitable for high-throughput screening.
In all proposed single-path routing schemes, a new path-discovery process is required once a path failure is detected, and this process causes delay and wastage of node resources.
Our discovery that Plk1 is required to initiate anaphase B will help to dissect the mechanisms that control the switch from metaphase to anaphase spindle dynamics required for chromosome segregation.
Support for this idea came from the discovery that CP190 is required for the enhancer-blocking activity of the gypsy Su(Hw) insulator and is a component both of this transposon insulator and of endogenous Su(Hw) insulators [ 52, 53].
As tests are performed on a large number of genes, stringent false-discovery rate control is required at the expense of detection power.
Our result is consistent with the recent discovery that tmRNA tagging is required for sporulation in Bacillus subtilis, another sporulating Gram-positive bacteria [40].
