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RNAi is a recent discovery, identified in mammalian cells in 2001, but it has rapidly advanced into a practical technique and is being used increasingly to investigate mammalian gene function.
Furthermore, de novo motif discovery identified the known high-affinity NKE exclusively within NKX2-5 DamID peaks.
De novo motif discovery identified the known DNA-binding site for both ELK1 and ELK4 as the only over-represented motif.
The de novo motif discovery identified well-known regulators closely connected to the OCT4 network as well as potential new regulators of pluripotency and differentiation.
In this study, DArT marker discovery identified 511 new polymorphic markers in hop, from 6,439 DArT clones, resulting in a frequency of polymorphism of 7.9%.
In 2005, a landmark discovery identified a gain of function mutation, JAKV617F, as being an essential mutational driver in many MPNs.
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Now Eve, a newer version, continues the work for automatic drug discovery, identifying potential malaria drugs at Manchester University.
Swirski and colleagues have already made one encouraging discovery, identifying IRA-B cells in people.
The aim of target discovery is the identification and validation of suitable drug targets for therapeutic intervention, whereas lead discovery identifies novel chemical molecules that act on those targets.
This represents the second example of NMD-based didentifyingentifying a novel truncating mutation in cancer.
This discovery identifies SALL2 as the third member of the Drosophila homeotic Spalt-like family of developmental transcription factor genes implicated in human disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com