Sentence examples for discovery compound from inspiring English sources

dosing and i.v. infusion to obtain steady-state brain penetration, along with blood clearance, oral exposure and oral bioavailability for each discovery compound, within a 24 hour in-life experiment and only a few (e.g., 3) animals.

The discovery compounded the perplexity and confusion raised by earlier detection of planets beyond the Sun's family, beginning in 1995.

The search had been prompted by an earlier discovery: compounds that bound to a similar gene receptor were highly effective in treating diabetics, the pharmaceutical industry's most lucrative market.

The 18 Allergan discovery compounds contain a variety of chemical moieties.

Many discovery compounds have low solubility but are potentially valuable as leads.

The second, was a long-term conventional Arrhenius stability experiment (8 weeks in five separate isothermal ovens), conducted in parallel on the same 18 discovery compounds.

A fast gradient HPLC method (cycle time 15 min) has been developed to determine Human Serum Albumin HSAA) binding of discovery compounds using chemically bonded protein stationary phases.

Applying snapshot PK studies to categorize the oral exposure of >1300 discovery compounds as low, moderate or high resulted in an attrition rate of 86%.

Profiling of discovery compounds usually includes separate assessments of solubility, permeability, and susceptibility to first-pass metabolism, which are the 3 most likely contributors to incomplete oral bioavailability.

Table 7 was generated for binning classifications of the 18 discovery compounds based on their predicted t98% values into two categories: stable (t98% ≥ 24 months) and unstable (t98% < 24 months).

The first, comprised a short term accelerated non-isothermal stability experiment (1 week in a LNISO oven by linear heating) on two compendial drugs and 18 discovery compounds with different pharmacophores.