When Alma follows in Ambrose's wake to Tahiti, a eureka moment of her own during a violent ball game triggers a discovery capable of pre-empting Darwin's in On the Origin of Species.
We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 µL of serum or plasma).
Eliciting the genius of John Milton, he rated the discovery "capable in the highest degree of being poetically treated," by the bard's very definition of poetry as "simple, sensuous, and impassioned".
Bioactive transformation products can be viewed as environmental designer drugs, built in nature by some of the same (bio chemical processes exploited by pharmaceutical manufacturers for drug discovery and capable of evading many commonly employed analytical techniques.
Understanding our health care delivery system as a CAS might transform our health care system into a new integrated adaptive discovery network capable of continuously, instantly and efficiently improving the safety, quality, and cost utility of the American health care system.
Current strategies in drug discovery are capable of producing new drug candidates with acceptable nonclinical absorption, distribution, metabolism, and excretion (ADME) properties. 1 However, translation of that ADME information, which is obtained either from in vitro systems or from animal species, into understanding of the behavior of the new drug in humans is not always straightforward.
Concomitantly, protein engineering has advanced to allow the discovery of polymerases capable of utilizing modified nucleotide analogs.
The discovery of proteins capable of converting 5-methylcytosine (5mC) to putative substrates for DNA repair introduced a novel and exciting conceptual framework for the investigation and ultimate discovery of molecular mechanisms of DNA demethylation.
The district was the location of several local quarries which opened throughout the region after the 1825 discovery of rocks capable of producing Rosendale cement in the nearby hamlet of High Falls.
We have therefore designed an approach to protein motif discovery that is capable of harnessing the information found in large-scale datasets, such as protein abundance, gene expression, localization, and post-translational modification.
Moreover, as they appear to mimic the clinical observations of shared cross-resistance between CDDP, CBDCA and CHIP, they may represent valuable preclinical evaluation models for the discovery of drugs capable of conferring responses in CDDP-refractory ovarian cancer.
