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The availability of quality data plays an important role in a successful vaccine discovery campaign.
During the tour of the Atira asteroids an opportunistic NEA discovery campaign is proposed to increase our knowledge of the asteroid population.
Several assays to monitor inhibition of Hsp90 function currently exist but are limited in their use for a drug discovery campaign.
Ligandcentric virtual screening techniques employ in most cases three-dimensional Gaussians in order to define a molecule's entire pharmacophoric properties (ideally of a co-crystallised ligand) [1] and have been applied successfully in many prospective and retrospective drug discovery campaign [2].
In the study of Lajiness at al. [8], 13 chemists reviewed sets of 2000 diverse compounds containing also a common set of 250 compounds, with the goal of removing those that are unacceptable for any reason (too complex, having too complicated synthesis, unsuitable for launching a drug discovery campaign etc): the objective was to see the consistency of chemists in picking "bad" molecules.
Key to the success of any lead discovery campaign is the ability to unambiguously detect and characterize the binding of test ligands to a given protein target.
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Computational techniques have become a vital part of today's drug discovery campaigns.
Drug discovery campaigns rely on the expert judgment of medicinal chemists for key decisions on which leads to pursue.
Many lead molecules identified in drug discovery campaigns are eliminated from consideration due to poor solubility and low cell permeability.
Three dimensional pharmacophores and pharmacophore searches are well established in virtual screening and have been applied successfully in many prospective and retrospective drug discovery campaigns [1].
In drug discovery campaigns, hit-to-lead is the stage during which the binding affinity between a newly identified molecule and a therapeutic protein target is optimized.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com