Discovery and validation of autosomal dominant Alzheimer's disease mutations.
We describe nutritional peptidomics for discovery and validation of bioactive food peptide and their health effects.
Here we present the discovery and validation of a potent herbicide that targets a critical metabolic enzyme that is required for plant survival.
Discovery and Validation of a Novel Class of Heat Shock Protein 90 (Hsp90) Inhibitors through Multi-modality Molecular Imaging of Chaperone Interactions in Living Subjects.
By revealing cellular pathways for scaffold-based and catalytic arrestin activation, the current papers provide fresh insights that might accelerate the discovery and validation of biased GPCR agonists as therapeutic agents.
The discovery and validation of epigenetic biomarkers linked to exposure, asthma, or both might lead to better epigenotyping of risk, prognosis, treatment prediction, and development of novel therapies.
Sophisticated bioinformatic computational tools and systems biology approaches are being applied to the discovery and validation of biomarkers, with substantial progress taking place.
High affinity antibodies are crucial both for the discovery and validation of biomarkers for human health and disease and as clinical diagnostic and therapeutic reagents.
With technological advances in PPI modulator discovery and validation of PPI-targeting agents in clinical settings, targeting of PPI interfaces as an anticancer strategy has become a reality.
We report the discovery and validation of a novel CHO cell engineering target for improving IgG expression, serpin peptidase inhibitor, clade B, member 1 (Serpinb1).
This effort has included the discovery and validation of new biomarkers of AKI.
