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By addressing such questions, however, we have already opted for an oblique style of reading, a change of perspective and the focus of attention reverts from 'context of justification' to 'context of discovery', analysing concrete subjects who, in concrete research settings, face demanding objects (a).
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Moreover, Metabochip-wide discovery analyses revealed two BMI-related loci, BRE (rs116612809, p = 3.6 × 10−8) and DHX34 (rs4802349, p = 1.2 × 10−7), which were significant when adjustment was made for the total number of SNPs tested across the chip.
In fact, for Caucasians, the effect sizes for the replication studies were greater than those observed in the discovery analyses.
The RECLU is a method of implementing clustering, differential expression analyses, and motif discovery analyses.
Recent developments in MS for "-omics" scale discovery analyses have been impressive.
One is that ERF was part of the discovery analyses for the QRS and QT GWAS.
In our discovery analyses, we found associations of ZNF385D and COL4A2 in comorbid cases, and of NDST4 with LI.
The genome-wide discovery analyses yielded a small genomic inflation factor for each egg weight, ranging from 0.981 to 1.014.
The unsuccessful replication could be due to false-positive findings from the discovery analyses, or differences in how atopy was assessed between the discovery and replication cohorts.
Markers with the strongest P-values in discovery analyses in ZNF385D, COL4A2 and NDST4 were carried forward for replication analysis in PING.
In total, the false discovery analyses provided very strong evidence that when multiple single cells had the same mutation, those variants were true somatic mutations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com