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Jennifer Doudna and Samuel Sternberg's "A Crack in Creation" describes another fortuitous discovery, a method that promises to revolutionize biotechnology by allowing us to change nearly any gene in any way in any species.
Even though this paper did not strictly provide a novel mechanistic discovery, a method like STOMP can change the way we approach fundamental biological problems and therefore represents a major advance to the life science toolbox.
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The discovery of a method for making induced pluripotent stem cell (iPS cells) has revolutionized the creation of pluripotent stem cell lines.
Berthollet's discovery of a method for the preparation of gunpowder from "superoxygenated potassium muriate" (potassium chlorate, a substitute for saltpetre) was implemented throughout France during the French revolutionary and Napoleonic wars in response to a shortage of saltpetre.
The recent discovery of a method of forming functionalized silica nanoparticles in situ in an aqueous sol gel process, and then cross-linking the nanoparticles to form a thin film, is an excellent example of a nanoscience approach to coatings.
The port relied on the discovery of a method that allowed Decays PS2 game files to be deciphered, thereby allowing the files to be ported to Windows.
This discovery provides a method to significantly increase the efficiency of reprogramming, enhancing the feasibility of the potential applications based on this technology, and a tool for basic research studies to understand the underlying reprogramming mechanisms.
As for gene-drug discovery, Riken developed a method of gene-drug discovery for rheumatoid arthritis [9].
FDR (False Discovery Rate) is a method to determine the threshold of P-value in multiple tests.
TILLING (Targeting Induced Local Lesions in Genomes), a general reverse genetic technique that combines traditional mutagenesis with high throughput methods for mutation discovery, is such a method.
FDR (False Discovery Rate) is a method to determine the threshold P-value in multiple tests and analysis through manipulating the FDR value.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com