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By determining the size of ∼22 nucleotides, and discovering the interaction of lin-4 with sequence complementary elements in a repeated sequence element in the 3′-untranslated region of lin-14 messenger RNA, they established at this time the basis for a new research direction in developmental biology, physiology and medicine.
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"What drove us to write this paper was the number of new drugs that have come out in the last four years," said Dr. Bailey, a clinical pharmacologist at the Lawson Health Research Institute, who first discovered the interaction by accident in the 1990s.
DSC analysis and microscopic morphology analysis discovered the interaction of CTAC and saturated hydrocarbon component of the crude oil, which can reduce the wax peak temperature and wax precipitation point of crude oil.
Since more then 1000 different human miRNAs have already been discovered, the interaction between miRNAs and mRNAs is highly complex and currently not completely understood.
We verified the mass spectrometry result with co-immunoprecipitation of Hsp90α and tPA in conditioned media from HT-1080 fibrosarcellscells, the cell line for which we originally discovered the interaction of extracellular hsp90α and MMP-2, and MDA-MB231 cells (data not shown).
However, a major challenge for gene set analyses is to discover the interactions among genes, hidden in gene expressions data.
Crossing mouse strains harboring different FGFs mutations with FGFRs mutant mouse models is necessary to discover the interactions between FGFs and FGFRs in skeleton development and homeostasis.
For each of the four gene groups (luminal-A gain, luminal-A loss, basal-like gain, and basal-like loss), our goal was to discover the interactions between mRNAs and their regulating miRNAs using their dual expression profiling data under the constraint of the reconstructed breast cancer subtype-trend target information.
In this paper, we designed an agent-based collaborative caching model, in which three roles of agents: the Capturer Agent, the Transmitter Agent and the Manager Agent are developed for discovering the intrinsic interaction relationships of caches.
Simultaneously calibrating all the reaction/transport rate parameters and discovering the gene/TF interaction network structure from available data does not appear to be feasible.
The present study was initiated as an approach to discovering the functionally relevant interaction partners of PrPC.
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