SPABBATS allows the accumulation of intermediates in the pathways, which permits discovering pathways missed by most traditional pathway analysis methods.
We were also interested in discovering pathways that are candidates for contributing to the observed insulin resistance.
While univariate statistics are well suited for investigating global burden and for discovering pathways implicated in ASD, multivariate machine learning methods are best suited to achieve optimal classification performance using all available gene annotations.
We discuss the connection of the proposed mechanism with the recently discovered pathway of active nucleosome reconstitution.
This newly discovered pathway consists of four enzymes encoded by mqnABCD genes and some unknown enzymes (Dairi 2009, 2012).
The AGE/RAGE system is a new discovered pathway implicated in the pathogenesis of several cardio-metabolic diseases (5– 8).
Type VI secretory pathway is a newly discovered pathway [ 57, 58], which spreads in Gram-negative bacteria, and plant and human pathogens as well [ 59- 61].
It is conceivable that TAF7L and associated regulatory factors in this newly discovered pathway may reveal potentially useful therapeutic drug targets to combat obesity and its related diseases.
To summarize the results from these three different testing examples, it appears that FBA has the ability to discover pathway cross-talks.
