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They also address some of the challenges of GWAS, such as the high rate of false discoveries, variation between patient cohorts, and accessibility of validation cohorts.
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In another key discovery, a variation of a gene called APOE was found.
"I won't forget the surprise at our discoveries of variations in our individual which in turn will serve to remind me how unique each living person is and not let me fall into the trap of stereotyping people.
Universities, on the other hand, thrive on discovery and variation as a source of innovation.
Historically, the starting point of ecological genetic research has been the discovery of variation within a natural population, i.e., a phenotypic polymorphism.
If this ambiguity is not detected, reads will be frequently mis-mapped to the wrong location in the genome, potentially leading to the false discovery of variations at positions that do not have any variations or other mis-interpretations of the mapping.
The discovery that variations occur randomly and are then transmitted genetically raised the possibility that change could be directed.
To better characterize the catfish transcriptome and improve discovery of variations derived from duplicated genes, a haploid transcriptome is needed.
The discovery of variations in the DNA sequence of tumor cells associated with clinical significance has been hurled ahead by next-generation sequencing technologies.
However, recent discoveries of unexpected variation in genome organization and regulation may reveal a heretofore unknown lack of homology between model animals and target animals that could account for a significant proportion of the weakness in predictive ability.
Though this statement is an extreme case of research findings being applied broadly out of context, it illustrates how discoveries of genetic variation between human groups can have wide-ranging social implications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com