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This article introduces the supplement Advances in Cancer and Brain, Behavior, and Immunity and outlines important discoveries, paradigm shifts, and methodological innovations that have emerged in the past decade to advance mechanistic and translational understanding of biobehavioral influences on tumor biology, cancer treatment-related sequelae, and cancer outcomes.
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An emerging drug discovery paradigm.
The current drug discovery paradigm allocates a short period of time (3 12 months) for the process of lead identification.
Prodrug interventions should be considered early in the drug discovery paradigm rather than as a technique of last resort.
Fragment-based drug discovery has emerged over the past 15 years as an effective lead discovery paradigm that is complementary to traditional high-throughput screening.
The wealth of RNA structural data generated by these structures has allowed computational chemists to employ a drug discovery paradigm focused on RNA-based targets.
This may explain why the currently available drugs, developed according to the classic drug discovery paradigm of "one-molecule-one-target," have turned out to be palliative.
The progress of the past decade has been driven increasingly by improvements in an integrated drug discovery paradigm that starts with smaller molecular starting points, termed scaffolds, and incorporates X-ray crystallography at the outset of the project.
Due to the multiple factors closely involved in the pathogenesis of these diseases, the classic drug discovery paradigm of "one molecule, one target" is limited in its ability to combat such complex diseases.
Prodrugs are becoming an integral part of the drug discovery paradigm in some large pharma companies, and a number of small biotech companies have been built around the design and application of prodrugs to improve drug candidates.
Fig. 1 Current drug discovery paradigm in antibiotics.
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