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On the other hand, the complexity of regulatory factors has grown substantially, and we have just started to uncover some underlying principles: although miRNAs are probably the best investigated class of noncoding RNAs, the recent discoveries of complex miRNA and ceRNA networks and nuclear miRNAs indicate that our understanding of miRNAs in PCa progression is far from complete.
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In 1967 he became a professor at the University of California, Berkeley, where he initiated a program of radio and infrared astronomy leading to the discovery of complex molecules (ammonia and water) in the interstellar medium.
This is why ad hoc discovery of complex periodic patterns in a database workload is a difficult and time-consuming task.
Discovery of complex patterns such as clusters, outliers, and associations from huge volumes of streaming data has been recognized as critical for many application domains.
In recent years, the development of highly sensitive mass spectrometry platforms and other high-throughput technologies has enabled the discovery of complex changes in the entire lipidome.
Although reptiles have traditionally been viewed as asocial, the recent discovery of complex social systems in lizards suggests that an animal's social behaviour may be shaped by its interactions with conspecifics early in life, as occurs in endothermic vertebrates.
Direct discovery of complex patterns from the audit trails faces a difficult problem of finding appropriate candidate patterns in a huge space of theoretically possible sequences of multisets of syntax trees and the values of parameters that determine a scope and periodicity of the patterns.
We previously employed this technique to stratify AML patients by signaling responses [13], map the complexities of the broader immune signaling network in primary murine cells [14], and automate the discovery of complex signaling relationships in primary human T cells using machine learning [15].
Recently, we have established an approach of immune-response profiling for the discovery of complex biomarkers predictive of treatment response [ 10].
Rapid advances in epigenetics have led to the discovery of complex mechanisms of gene regulation involving phenomena such as DNA methylation and chromatin modifications.
The discovery of complex archaea that are the closest living relatives of eukaryotes is most compatible with the symbiogenetic scenario for eukaryogenesis.
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