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These landmark discoveries established sirtuins as important players in epigenetics and triggered the explosion of research interest in sirtuins.
Nevertheless, these discoveries established that the genome contains sequences that act against malignant transformation by inducing apoptosis.
On one hand, our findings unraveled cellular phenotypes likely to be involved in the observed developmental defects; on the other hand, these discoveries established LS as a ciliopathy-associated disease.
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Recent discoveries establish that the Homo sapiens groups who arrived in Europe some 45,000 years ago had already attained the self-awareness, creativity and technology of early modern people.
Considerations of this kind much reduce the evidential value of discoveries establishing, for example, that the number of graves in Attica and the Argolid (the area round Argos) increased dramatically in the later Dark Age or that there was a serious drought in 8th-century Attica (that is the admitted implication of a number of dried-up wells in the Athenian agora, or civic centre).
These discoveries establish the complete reversibility of poly(ADP-ribosyl)ation as a regulatory modification.
Thomson's discovery established the particulate nature of electricity.
Her discovery established that fully modern humans had been in Australia for longer than any European expected.
This highly original discovery established his international reputation as a geneticist and eventually won him the Nobel Prize.
Challands said the discovery established the Isle of Skye as an area of major importance for research into the mid-Jurassic period.
His discovery established the world's first human embryonic stem cell line and launched stem cell research into the scientific mainstream.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com