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The estimated number of true discoveries, corresponding to an estimated 44 chemicals showing true cytotoxicity association with rs13120371, is subject to considerable sampling variation.
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If adequate exploration efforts were to be made, surely at least some of those areas would yield significant discoveries, corresponding at least to the P95 probabilistic values of yet-to-find economically recoverable resources.
The false discovery rate (FDR) corresponding to each NES was then calculated [30].
The proportion of false positives was controlled by calculating the false discovery rate (FDR) corresponding to each NES [26].
To account for multiple hypotheses testing, GSEA normalizes the ES for each gene set to account for variation in set sizes and calculates a false discovery rate (FDR) corresponding to each normalized ES.
'fdr' the false discovery rate (FDR) corresponding to the p-value.
The proportion of false positive was then controlled by calculating the false discovery rate (FDR) corresponding to each NES.
We then compared the distribution of gene pair classification accuracy between actual and randomized data, and calculated the false discovery rate (FDR), corresponding to the likelihood of finding an apparently accurate classifier due to chance.
We extracted the top 1,000 genes from the blood eQTL browser [ 21] and compared the percent variance explained by individual differences with that for the 1,000 genes with the smallest eQTL effects, truncated at p < 0.001 (at which there is an approximate 25%% false discovery rate) and corresponding to the 6,700th to 7,700th ranked eQTL genes.
Raw P values were adjusted for multiple testing using the Benjamini-Hochberg procedure47 and a significant association was based on a threshold of false discovery rate of 0.1 (corresponding to raw P value of 3.03 × 10−6).
De novo motif discovery on FASTA sequences corresponding to windowed peaks was performed using MEME-ChIP.
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