After this seminal discovery, evidence accumulated in recent years has supported the idea that patients harbouring these mutations in their tumours show response to EGFR tyrosine kinase inhibitors [ 6, 7].
For data mining efforts, exceptions might occasionally be made if knowledge derived from proprietary data could not possibly be obtained on the basis of public domain data (which might apply, for instance, to fundamental analyses of drug discovery data accumulated in the pharmaceutical industry over time).
This flexible approach would address the expectation that new information or discoveries will accumulate at such a rapid pace that external information could affect the conduct of trials midstream and could thus effectively guide their modification.
Yet the accumulated discoveries yielded an analysis of deeper and deeper levels of linguistic structure of the type associated with discoveries in the natural sciences.
More medical knowledge or discoveries are being accumulated in a constant flow.
If the accumulated discoveries do not affect the increase in resources, the second term on the RHS of Eq. (16) vanishes.
Text mining will never replace other methods of drug discovery, but tapping the accumulated medical expertise locked up in old documents could, it seems, provide some helpful shortcuts.
The proposal, in negotiation with Daewoo's lead creditor, the government-owned Korea Development Bank, reportedly asks for guarantees in case of discovery of hidden debts accumulated by the bankrupt manufacturer overseas.
We made the unexpected discovery of 10 mutations accumulated in strain W3110 after Kohara et al. generated the lambda clone library that was sequenced.
Since its discovery, overwhelming evidence has accumulated to support the role of VEGF as a principal regulator of tumor-associated angiogenesis and as an activator of tumor proliferation, invasion, and metastasis in mammals (reviewed in Dvorak, 2002; Hoeben et al., 2004).
