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More recently, one of the major β-defensins produced in skin, β-defensin 3, has been discovered to function as a melanocortin receptor ligand in vivo and in vitro, but its biophysical and pharmacological basis of action has been enigmatic.
However, ROS have also been discovered to function as important regulators of many biological processes, such as cell growth and development, hormone signaling and stress responses [1].
Histones, as chromatin structure proteins, have recently been discovered to function as DAMPs involved in multiple cellular processes.
DOI: http://dx.doi.org/10.7554/eLife.00672.014 To the best of our knowledge, this is the first enzyme discovered to function as a catalytically efficient MPD.
The bipotent coregulator TAZ was recently discovered to function as a coactivator of Runx2 and as a corepressor of PPARγ, thus promoting osteogenesis while blocking adipogenesis [ 53].
The gene cluster rrnS-CR trnI-trnQ-trnM-nad2 in the proposed ancestral mitogenome has been discovered to function as a hot spot for gene rearrangements in arthropod mitogenomes.
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To date, all the riboswitches that have been discovered appear to function as repressors of gene expression in response to dynamic primary metabolites [41], [43].
DExD/H-box protein Prp16 was first discovered to have a function in promoting the fidelity of branch site recognition [ 159 , 160]
lncRNAs have been discovered to perform regulatory functions in various biological processes, including cell cycle, pluripotency, cell differentiation and development, due to its special property to interact with both DNAs and proteins 35, 36.
As our results point to an anti-apoptotic effect of AtTCTP on mammalian BAX-induced PCD in planta, and as plant proteins have been discovered to have comparable functions to mammalian Bcl-2 family proteins, it could be assumed that AtTCTP acts in a similar way as mammalian TCTP.
The mature form of nerve growth factor (NGF) derives from a precursor, proNGF, which was recently discovered to exert crucial brain functions responsible for mood and cognitive activities [23].
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