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We have recently discovered that activation of the histamine H3-receptor, in cardiac sympathetic neurons, can modulate intracellular Na+ and Ca++ ion activities both of which can regulate neurotransmitter release, via carrier-mediated release of norepinephrine or Ca++-dependent exocytotic release.
Using functional MRI, it was discovered that activation of the right posterior hippocampus accompanied searching for an object when reference was made to the boundary cues.
Instead, it was discovered that activation of a protein, called BZR1, reprogramed gene expression to 'switch off' immune signaling in response to brassinosteroids.
Moreover, using lentiviral transduction of SCN slice cultures, we discovered that activation of AT motifs is under circadian control in SCN and is compromised by the Zfhx3 Sci mutation.
In investigating cooperation between polarity loss and oncogenic pathways in epithelial tumorigenesis, we discovered that activation of the small GTPase, Ras (Ras85D V12, referred to as Ras ACT herein) or activated Notch (Notch ICD, referred to as Notch ACT herein) cooperated with scrib loss-of-function to form massive invasive tumours (Brumby and Richardson, 2003).
Recently, it was discovered that activation of NALP3 in intestinal epithelial cells limits pathogen colonization and dampens the ensuing intestinal inflammation during the early course of infection, and the polymorphisms of NALP3 have been demonstrated to functionally link with the susceptibility to inflammatory disease [ 70 ▪].
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We discovered that loss of RSP5 phenocopies loss of OLE1, suggesting that Rsp5 could be one of the early sensors of temperature, which coordinately regulates fatty acid synthesis and activation of the heat shock response.
By comparing the time courses of the physiological activities and behavioural responses, it was discovered that the activation of LA neurons, rather than that of ILSCm neurons, temporally correlated with the US-elicited UF in ChR2 ILSCm mice (Fig. 4f and Supplementary Fig. 8).
Additionally, we discovered that constitutive activation of HacA results in the down regulation of the AmyR transcription factor and the AmyR regulon, which includes the most abundantly produced extracellular glycoproteins, thereby reducing import of new proteins into the ER.
It was discovered that thermal activation of the stitched network resulted in partial repair of delamination and matrix cracks and substantial recoveries (more than 50%) in the stiffness, ultimate load and energy absorption properties of the fractured T-joint.
The authors discovered that the activation of the Hsp70 gene lead to rapid loss of nucleosomes that 'freed' the gene and sequences further downstream for unobstructed access of the polymerase to initiate transcription.
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CEO of Professional Science Editing for Scientists @ prosciediting.com