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However, it might be harder to interpret the biological meaning of a discovered target gene, if little or no functional information could be found for it.
More recently, mammalian members of the TPC (two-pore channel) family – the newly discovered target of NAADP [14 16] – exhibited sensitivity to luminal Ca2+ whereby increasing luminal Ca2+ concentrations enhanced channel activity in lipid bilayers [17,18].
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Newly discovered targets of Myc repression include a set of microRNA genes, the repression of which contributes to tumor formation.
Note that drugs whose discovered targets were not annotated in the DrugBank database were used in this study [ 23].
mRNAs with the motif may represent newly discovered targets of mTORC1 dependent translation (Additional file 2: Table S6).
Ongoing clinical trials will shed light on the potential druggability of these interactions, in addition to other newly discovered targets.
Interestingly, the newly discovered targets (bold) and those targets not annotated in the DrugBank (underlined) could also be discovered by the new DRS predictions.
This dysregulates cell survival by targeting the newly discovered targets, SHMT-2 and MECP-2, respectively; apoptosis was induced by the inhibition of miR-370 or miR-373, and also by the overexpression of SHMT-2 or MECP-2.
A number of cap-snatching inhibitors discovered targeting the endonuclease site have been reported including 4-substituted 2,4-dioxobutanoic acid derivatives, flutimide (Fig. 5), and N-hydroxamic acid/ N-hydroxyimide.
Experimental results show that our proposed methods are effective in discovering target URLs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com