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Since Gross and Lapiere firstly discovered matrix metalloproteinases (MMPs) as important collagenolytic enzymes during amphibian tadpole morphogenesis in 1962, this intriguing family of extracellular proteinases has been implicated in various processes of developmental biology.
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Statistical validation involves verification of ChIP data for transcription factor-binding sites, using tools for motif discovery and quality assessment of the discovered matrices.
During the testing, I discovered a matrix effect associated with the degree of hydration of the material being analyzed, and I found that an intense pre-sputter reduces the observed effect.
In PCA, the data ({boldsymbol {x}_{i}}_{i=1}^{N}) is used to discover the matrix D whose column vectors span the space of the data (up to noise) and w i are the transformed representations of x i.
Last month astronomers discovered water, the matrix of life, on a planet orbiting a distant star.
"I was, like, 'O.K., Let's see what happens.' " Rose and Dovell began cooking skins of srPET in the oven of their rented house and discovered that the matrix melted fully at two hundred degrees Celsius.
Fibulin-5 is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo.
Secreted OPN has been discovered in tissue matrix, including bone, fibroblast, osteocyte, dendritic cells, macrophages, and activated T cells [ 22].
We and others recently discovered that following matrix detachment, untransformed human mammary epithelial cells robustly upregulate pyruvate dehydrogenase (PDH) kinase 4 (PDK4) to inhibit PDH and attenuate the flux of glycolytic carbon to the TCA cycle.
Likewise, many previously discovered molluskan shell matrix genes do not have clear homologues in the Lottia genome (See Additional File 3 for results of these searches against Lottia genome traces).
In this study, we discovered that soft matrices promote CM dedifferentiation, as evidenced by CM rounding, myofibrillar disassembly, increased CM cell division, and clonal expansion.
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