Using primary mouse embryonic fibroblasts (MEFs) and ESCs derived from the Grp94+/+, +/− and −/− embryos, we discovered that in response to ER stress, GRP94 depletion results in compensatory upregulation of specific ER chaperones and suppression of ER stress-induced splicing of XBP-1, a downstream target of IRE1 signaling pathway.
Our laboratories have discovered that, in response to inflammatory mediators, bone marrow cells readily produce nitric oxide.
Although we found PKA and Sch9 do not regulate Maf1 through the same mechanism, we here discovered that in response to Sch9 loss or rapamycin treatment, which also inhibit Sch9, PKA hyper-activation decreases Maf1 protein amount.
That could be the greatest danger of all for Israel: to wake up one day and discover that, in response to the messy and turbulent Arab democratic awakening, the Jewish state sacrificed its own democratic character.
They discover that, in response to endoplastic reticulum (ER) stress, zebrafish embryos have three distinguishable gene expression responses, and only one of these responses leads to FLD ('stressed UPR'stressed
A newly discovered hormone produced in response to exercise may be turning people's white fat brown, a groundbreaking new study suggests, and in the process lessening their susceptibility to obesity, diabetes and other health problems.
The proteins involved in drug uptake in breast cancer tissue have shown to play an active role in drug resistance [1], and we have in a previous study discovered glycoproteins involved in response to tamoxifen, distinguishing recurring from non-recurring breast cancer patients [2].
With that in mind, the two strains were first compared entirely separately from each other to discover expression differences in response to pathogen exposure for each strain.
Facebook initially didn't disclose when it discovered the bug, but in response to TechCrunch's inquiry, a spokesperson says that it was discovered and fixed on September 25th.
