A novel series of biaryl phenoxyacetic acids was discovered as potent, selective antagonists of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2).
OKY-1581 OKY-1581E -2-methyl-3-[4- pyridin-3-ylmethyl phenyl]prop-2-enoic was discovE -2-methyl-3-[4- pyridin-3-ylmethyl phenyl]prop-2-enoicth ozagrE -2-methyl-3-[4- pyridin-3-ylmethyl phenyl]prop-2-enoiccity in micE -2-methyl-3-[4- pyridin-3-ylmethyl phenyl]prop-2-enoic
A novel class of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones has been discovered as potent and selective inhibitors of the EGF-R tyrosine kinase family.
A series of novel 2,4-diarylaminopyrimidine derivatives of AZD9291 were discovered as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
A novel family of 1,3,5-trisubstituted 1,2,4-triazoles was discovered as potent and selective ligands for the δ opioid receptor by rational design.
Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE2 2a stimulated uterine motility.
Eotaxin-1 is a member of the CC chemokine family and was originally discovered as an eosinophil-selective chemoattractant.
Eotaxin-1 was originally discovered as an eosinophil-selective chemoattractant and may play a role in a number of chronic inflammatory diseases, cancer, and other gastrointestinal disorders.
Recently, UcnII and UcnIII have been discovered as potential endogenous agonists selective for CRF2 known to be involved in brain functions such as learning and anxiety, as well as in cardiovascular functions.
In our previous transcriptomic analyses of the laser-capture microdissected GBM vessels, the insulin-like growth factor-binding protein-7 (IGFBP7) was discovered as a highly upregulated selective biomarker of GBM vessels (Pen et al, 2007).
