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We assume that we use arrays with 1 M markers for models A and B. To be able to capture rare variants, we assume 10 M-marker arrays for model D, and 100M-marker arrays for model E. Figure 4 shows the expected number of causal variants that will be discovered as a function of the number of cases in a case-control study, with equal number of controls.
Figure 3 shows the median number of variants discovered as a function of average target coverage for SNPs and INDELs, for each capture experiment.
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Secretin was first discovered as a gastrointestinal hormone with its function in stimulating pancreatic flow [4].
13 It has been described to be involved in neurite outgrowth and plasma membrane organization, and non-myristoylated BASP1 has been discovered as a co-suppressor of WT1 function (Wilms' tumor suppressor protein 1).
Dear Editor, Histone deacetylase 6 (Hdac6) was discovered as a deacetylase of α-tubulin and functions in cell migration, immunity and resistance to virus infection in vitro (Hubbert et al., 2002; Valenzuela-Fernandez et al., 2008).
Additionally, recently, a group of endogenous, small, noncoding RNAs, called microRNAs (miRNAs), has been discovered as a new class of regulators of gene function [ 3- 5].
Adiponutrin was originally discovered as a nutritionally regulated adipose-specific transcript of unknown function (Baulande et al., 2001).
Occludin, first discovered as a 65kDaa protein in chicken, has been shown to play an important role in regulating tight junction barrier function [ 22].
PRAS40 was originally discovered as an Akt substrate of unknown function [37].
VEGF was discovered as an endothelial cell mitogen and functions as an angiogenesis stimulator [ 69].
To evaluate the chemotype discovery on the complete data set, we plotted the fraction of the discovered chemotypes as a function of the fraction of the ranked data set.
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