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On the basis of the reported weak activity of some flavonoids on phosphatases, we discovered a lead that originated a new class of highly active LMW-PTP inhibitors; these compounds inhibit also PTP-1B and are active in cellular assays.
Background: In 2010, Médecins Sans Frontières discovered a lead poisoning outbreak linked to artisanal gold processing in northwestern Nigeria.
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Together with anticancer activity in vivo, these works not only discovered a new lead compound for cancer therapy with low toxicity, but also provided evidence for using H. japonicum as an anti-cancer herb.
Instead, to their surprise, they discovered an inner lead coffin, carefully soldered on all sides, its lid decorated with a cross.
In our earlier studies, we have discovered a potent antibacterial lead molecule from 1,3,5-triazine (first generation) and its subsequent optimization till its tenth generation results much more advanced analogue with enhanced activity and less toxicity [ 1].
The new water absorbed lead from Flint's aging pipes, and researchers discovered a corresponding increase of lead levels in the bloodstreams of local children.
The severity of the outcome (i.e., preeclampsia) may be related to the magnitude of lead exposure because we discovered a weaker association between blood lead and PIH when excluding women with preeclampsia.
Kramer retraced his Atlanta conversation with Pendray, returned to his metallurgy books, and discovered a diagram that might lead to a crucial refinement.
As Nokia's competitors have discovered, a single misstep can lead to disaster.
I discovered a secret tunnel that led away from the lakeside castle, out of the cellar and all the way under the water, to a secluded cove.
A11 SCIENCE Type 2 Diabetes Gene Found Scientists have discovered a variant gene that leads to a sizable extra risk of Type 2 diabetes and is carried by more than a third of the American population.
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CEO of Professional Science Editing for Scientists @ prosciediting.com