Sentence examples for discover variations from inspiring English sources
The management pathway for the return of pre-defined clinical results or incidental findings (Kaye and Hawkins 2014), to some participants, was developed because the extensive sequencing undertaken in UK10K meant it was highly likely that researchers would discover variations that could have health or reproductive significance for the participant.
In the present study, we were also able to discover variations from LCLs with larger sizes, such as 5 entire chromosome duplication, and similar to the findings of Simon-Sanchez et al, we were able to detect 10 variations with sizes larger than 3 mb.
Furthermore, the intention is to assess effects of prophylactic interventions and discover variations in SSI.
As such, it will be extremely difficult to resequence the genome and confidently discover variations.
More importantly, the QUALYCARE study could discover variations in the underlying individual reality of place of death for people dying from cancer and their families.
Even with genome-wide resequencing of expressed genes, an investigator may need a locus-focused effort to discover variation in regulatory regions, or there may me a need to probe for the newly-discovered variants in a larger set of individuals.
Based on this information, reads can be grouped by position and assembled to discover variation.
Availability: http://vcftools.sourceforge.net Contact: [email protected] One of the main uses of next-generation sequencing is to discover variation among large populations of related samples.
Next-generation sequencing can be used both for de novo sequencing of genomes (requiring sequence assembly) and for sample re-sequencing that compares the resulting data to the reference sequence to discover variation present in the sample.
This suggests that more of these newly discovered variations may play a role in disease or drug response.
This genomic 'dark matter' should be taken into account in every resequencing study, especially when evaluating size or distribution of the discovered variations.
