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Various biochemical affinity purification methods provide direct approaches to discover target proteins binding small molecules of interest for this purpose [3 6].
With ethanol as the target product, OptKonck was applied to discover target gene(s) knockouts.
To discover target candidates, we associated coding genes residing in a given search radius to the identified regions, using a "seq2gene" mapping strategy.
These pilot studies provide an exciting proof of principal for the application of computational methods in aptamer design and provide the basis for the test of the use of our technique to discover target specific aptamers.
Pham TH et al 54 developed a method that combined three different expression datasets with the same ChIP-chip binding data with a relaxed threshold (P-value = 0.005) to discover target genes based on rule induction.
This dataset provides a unique opportunity to discover target sets of genes in core sorghum varieties that may be useful for modulating gene expression in a tissue-dependent manner.
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Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.
We designed several approaches to discover targets for multiple-target cocktail therapies.
The existence of interactions between drugs and network reactions suggests a potential way to discover targets.
Determining the glycome in different disease states is important for the future identification of structure-function relationships and to discover targets for diagnostic biomarkers [ 25, 39, 40].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com