Exact(2)
However, there remains an intense effort to discover safer estrogens that selectively regulate ERα or ERβ, as alternatives to the estrogens currently used in HT regimens that non-selectively regulate both ERs.
These findings have resulted in a marked decline in the use of HT [9], and created a large unmet need to discover safer estrogens for HT that lack the cancer-inducing properties, but retain the beneficial effects on menopausal symptoms.
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