Exact(7)
As a Reynolds foundation fellow, he applied high dimensional molecular tools to discover novel pathways in atherosclerosis and heart failure, attracting in the process Investigator awards from the American Heart Association and the Heart Failure Society of America.
While a pathway is usually defined as a set of genes known to share a specific function, pathway boundaries are frequently difficult to assign, and methods that rely on such definition cannot discover novel pathways.
These studies further demonstrate the potential to discover novel pathways through discovery-oriented expression profiling.
In order to discover novel pathways that regulate stem cell self-renewal, we have applied functional genomics using an RNAi library targeting ~8,000 genes involved in cancer.
This research has the potential to discover novel pathways, not previously known to play a role in the disorders studied, and ultimately lead to novel treatments.
Future studies identifying further dysregulated miRNAs may discover novel pathways involved in islet dysfunction that could provide novel therapeutic targets for diabetes treatment.
Similar(53)
Discovering novel pathways to increase the well-being of healthcare workers is essential.
Discovering novel pathways for the activation and transformation of white phosphorus (P4) is important for the ongoing search for new, systematic entries to polyphosphorus and organo-phosphorus compounds.
Our interest has focused on discovering novel pathways that regulate the differentiation of Treg cells, which represent the major anti-inflammatory Th component.
While most members of this enzyme family, such as that from a model cyanobacterium Synechocystis sp., are involved primarily in nicotinamide adenine dinucleotide (NAD) salvage/recycling pathways, its close homolog in a category-A biodefense pathogen, Francisella tularensis, likely plays a central role in a recently discovered novel pathway of NAD de novo synthesis.
Furthermore, we discuss how the integration of genomic data can be used to discover novel transcriptional pathways that may be modulated as part of therapeutic strategies for the treatment of obesity.
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