The goal is to gain significant understanding about this patient population, discover new principles of pathophysiology, identify novel pharmacologic targets, and streamline further drug development.
Conversely, quantitative theoretical predictions sometimes show that general mathematical and physical laws are incompatible with otherwise mundane observations, forcing us to reconsider our assumptions and leading us to discover new principles.
In an effort to discover new principles that govern gene expression in Arabidopsis thaliana, we integrated and analyzed publicly available whole-genome microarray data for this model plant.
Nanotechnology is exploring matter at the mesoscale and holds promise for discovering new principles, Dr. Laughlin said.
This highlights the continuous interest in laboratory screening of medicinal plants, not only to determine the scientific rationale for their usage, but also to discover new active principles.
The first, he says, "discovers new historical principles of geography and chronology, the two ideas of history, and thence the principles of universal history lacking hitherto" (Vita, 167), while the latter "discovers new principles of poetry, both of song and verse, and shows that both it and they sprang up by the same natural necessity in all the first nations" (Vita, 168).
Future progress in this area will require creative computational approaches to help discover new mechanisms and principles of miR-regulated gene expression.
The provocative "Górniak hypothesis" was a significant contribution to the ongoing "uniqueness debate", and it reinforced Maner's claim – which he made at the same ETHICOMP95 conference in his keynote address – that information technology "forces us to discover new moral values, formulate new moral principles, develop new policies, and find new ways to think about the issues presented to us".
In the past three decades, research along these lines has taken numerous directions, and each new generation of investigators has discovered new physicochemical principles and chemical schemes by which the release properties of materials can be altered.
These results are encouraging and demonstrate that in principle it is possible to discover new complexes in cryo electron tomograms in an efficient manner.
Screening highly selective ionophores from a large amount of ionophores is the principle and most realizable method to discover new ionophores used in ion-selective electrodes (ISEs).
