Exact(5)
software package, using the steepest descent minimization algorithm in the discover module of Insight II.
The partial atomic charges were assigned to each structure using CVFF force field using Discover Module in Insight II.
Local simulated annealing and energy minimization during modeling steps were performed via the Discover module with cvff force field.
The default version of AMBER was provided with the Discover module of InsightII molecular modeling suite (Accelrys, San Diego, CA).
The structures of quercetin, myricetin and chrysin were built with the Builder module in InsightII and minimized with the Discover module.
Similar(55)
We apply a random walk algorithm to these networks to discover modules of closely interconnected genes and build communities using distances derived from the random walk process.
Specialized algorithms for bipartite networks have also been developed, such as SAMBA, that integrates additional biological data to discover modules [ 105].
The iBBiG bi-clustering algorithm is optimized for module discovery in sparse noisy binary genomics data and can be used for meta-GSA of multiple genomics datasets, to discover modules: groups of phenotypes whose differential gene expression profiles are enriched in the same gene sets.
To discover modules associated with known breast cancer clinical covariates, 21 normalized breast cancer gene expression datasets (3875 gene expression profiles, see Supplementary Table S1) annotated with 107 clinical covariates were obtained from the GeneChip Ontology Database (Liu et al., 2011).
We found that MBPLS always failed for all 50 simulation data in that it assigns totally different variables and samples to the discovered module.
We found that those dynamic interactions tended to concentrate on a few miRNAs (e.g. miRNA-936), and were more likely present on the miRNA mRNA pairs outside the discovered modules.
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