Yet, shortcomings were also discovered, mainly concerning the reliability of the scales.
As many great discoveries, the phenomenon of cosmic rays was discovered mainly accidentally, during investigations that sought to answer another question: what are sources of air ionization?
The system for political primaries is broken and the superdelegate issue -- discovered mainly by people who never objected to their status before -- is just one problem.
On the other hand, tumor suppressors have been discovered mainly by molecular genetics approaches.
The anorectic effect of nesfatin-1 was discovered mainly after directly administering it into the brain of rodents [1].
Such MTL activations and lesion-related effects were discovered mainly using tasks that required retention of associations, such as object-to-location links (for reviews see Ranganath and Blumenfeld, 2005; Cashdollar et al., 2011).
Moreover, risk alleles have been discovered mainly by using case-control studies, which, although efficient for the discovery of disease associated single nucleotide polymorphisms, are suboptimal for evaluating their performance as predictors of risk.
With a very rare incidence in Europe, 3 the V180I mutation was geoepidemiologically discovered mainly in Japan, and has turned out to be the most common cause of gPrD in Japan.
Of the ∼60 loci associated with type 2 diabetes that have been discovered mainly from studies of European ancestries, ∼50 loci are represented on the Metabochip (ESM Table 2).
The limitations of both functional enrichment and network analysis are the quality and comprehensiveness of databases available, including the nature of the stored information (e.g. limited knowledge, interaction discovered mainly in vitro), as well as their algorithms, which do not or only very limited allow for dynamic network modelling.
