Studies have discovered linkages between AR and androgen levels and hepatocellular carcinoma in humans and animals [reviewed by Kalra et al. (2008)].
Finally, none of the available tools provides a downstream analysis that is able to discover the linkage of differentially methylated genes.
In the first stage of our study we analysed five microsatellites scattered across an independently discovered MS linkage peak in 17q11.2.
Therefore, we have discovered the linkage of two different units.
The other was discovering the linkage of increased expression of hPGFS to multiple tumours.
This gene was initially discovered by linkage studies to be associated with autosomal dominant hypercholesterolemia, 27 for which new causal mutations were identified in 2003.
Many of the important genetic risk factors for SLE have been discovered through linkage and association studies, and the body of work in this area is impressive.
FOXP2 gene, which encodes a neurally expressed transcription factor, was discovered through linkage analysis of a large family who had developmental verbal dyspraxia (DVD) or childhood apraxia of speech (CAS) [ 7, 8].
The suggestive QTL, for sex ratio in the adult worm population (0.4-40.7 Mb; OARv2.0) and packed cell volume after second challenge (6.6-44 Mb; OARv2.0), were discovered using linkage analysis with SNP data.
The Overall maximum LOD score for the chromosome 12 peak in the Total group was 1.11 in Category 5. We did not discover any additional linkage peaks in the gender-stratified analyses.
