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Thus, the incapability to discover functional gene products or a low detection frequency during function-based screens of metagenomic libraries might be a result of the inability of the host to express the foreign genes and to form active recombinant proteins.
A fundamental goal here is to discover functional modules or protein complexes in order to predict the function of unannotated proteins.
Compared with other strategies, shotgun library was much more common and easier to operate in discover functional enzymes.
The scheme is illustrated using functional magnetic resonance imaging (fMRI) time series to discover functional brain networks.
Thus, isolated cardiomyocytes have been powerful tools to discover functional changes of individual cardiac myocytes in response to stimuli.
The NeuCube framework can be used not only to discover functional pathways from data, but also as a predictive system of brain activities, to predict and possibly, prevent certain events.
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Rather, the intent was to genotype a maximum number of SNPs either known or suspected of being functionally relevant – with newly discovered functional variants to be added in additional panels in the future.
Advanced genomic approaches are paving the way for discovering functional miRNA targets and understanding how miRNAs execute their function (Hanina et al., 2010; Leung et al., 2011; Helwak et al., 2013).
ADARB2 is a very large gene spanning more than 500Kb in chromosome 10, but our analysis narrows the association to a region of approximately 100Kb that could be followed-up by fine mapping or sequencing for discovering functional variants and to provide a better understanding of the function of these genes in human aging.
However, this methodology is not effective at discovering functional peptides such as activators for GPCRs.
Thus, our study has established a robust in vivo platform for functional cancer genomics and has discovered functional breast cancer mutations.
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